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Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses

Pickup, D.M.; Moss, R.M.; Qiu, D.; Newport, R.J.; Valappil, S.P.; Knowles, J.C. and Smith, M.E. (2009) Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses. Journal of Chemical Physics, 130 . Article Number: 064708. ISSN 0021-9606

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Official URL: http://link.aip.org/link/?JCPSA6/130/064708/1

Cited 6 times in WoS

Abstract

Antimicrobial gallium-doped phosphate-based glasses of general composition (P2O5)0.45(CaO)0.16(Na2O)0.39-x(Ga2O3)x (where x = 0, 0.01, 0.03 and 0.05) have been studied using the advanced synchrotron-based techniques of Ga K-edge X-ray absorption spectroscopy (XAS) and high-energy X-ray diffraction (HEXRD) to provide a structural insight into their unique properties. The results show that the Ga3+ ions are octahedrally coordinated. Furthermore, substitution of Na2O by Ga2O3 strengthens the phosphate network structure because the presence of GaO6 octahedra inhibits the migration of the remaining Na+ ions. The results are discussed in terms of the use of Na2O-CaO-P2O5 glasses as controlled-delivery devices for antimicrobial Ga3+ ions in biomedical applications. We are thereby able to relate the atomic-scale environment of the Ga3+ ions beneficially to the glass dissolution, and thus to their ability to disrupt bacterial cell activity by usurping the role of iron.

Item Type:Article
Additional Information:Published online 13 February 2009
Uncontrolled Keywords:ABSORPTION FINE-STRUCTURE; MAS-NMR; DIFFRACTION; INFECTION
Subjects:R Medicine > RK Dentistry
Departments, Research Centres and Related Units:Academic Faculties, Institutes and Research Centres > Faculty of Medicine > School of Dental Sciences
DOI:10.1063/1.3076057
Publisher's Statement:Copyright 2009 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses D. M. Pickup, R. M. Moss, D. Qiu, R. J. Newport, S. P. Valappil, J. C. Knowles, and M. E. Smith, J. Chem. Phys. 130, 064708 (2009), DOI:10.1063/1.3076057 and may be found at http://link.aip.org/link/?JCPSA6/130/064708/1
Refereed:Yes
Status:Published
ID Code:1111
Deposited On:27 May 2009 12:53
Last Modified:22 Feb 2012 15:51

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