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Bioactive functional materials: a perspective on phosphate-based glasses

Abou Neel, Ensanya A.; Pickup, David M.; Valappil, Sabeel P.; Newport, Robert J. and Knowles, Jonathan C. (2009) Bioactive functional materials: a perspective on phosphate-based glasses. Journal of Materials Chemistry, 19 . pp. 690-701.

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Abstract

The general trend in biomaterials is to use and employ materials that play an active role in tissue regeneration rather than passive and inert materials. Therefore, understanding how a material interacts with the surrounding environments, including cells and tissue fluid, allows material design to be tailored so that implants can be constructed to promote a specific biological response, helping them better perform their function. This class of materials has been described as the “Third Generation” of biomaterials. Phosphate based glasses fall into this category and it has been shown that the properties of these glasses can be tuned via their composition according to the desired end application. These glasses can be prepared as melt quenched or sol-gel bulk form suitable for potential hard tissue engineering applications and as vehicles for antimicrobial agents. They can also be prepared as fibres suitable for soft tissue engineering applications such as those involving muscle, ligaments, and tendon, where, like the fibres, the tissue has a high degree of anisotropy.

Item Type:Article
Additional Information:First published as an Advance Article on the web 4th November 2008. Issue 6.
Uncontrolled Keywords:IN-VITRO BIOACTIVITY; SINUS FLOOR ELEVATION; POROUS-SURFACED IMPLANTS; CONTROLLED-RELEASE GLASS; ENHANCED OSTEOCONDUCTIVITY; STREPTOCOCCUS-SANGUIS; METAPHOSPHATE GLASSES
Subjects:R Medicine > RK Dentistry
Departments, Research Centres and Related Units:Academic Faculties, Institutes and Research Centres > Faculty of Medicine > School of Dental Sciences
DOI:10.1039/b810675d
Refereed:Yes
Status:Published
ID Code:1163
Deposited On:02 Jul 2009 12:39
Last Modified:19 May 2011 18:18

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