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Investigating the nephrogenic potential of mouse embryonic stem cells and their derivatives

Rak-Raszewska, Aleksandra (2010) Investigating the nephrogenic potential of mouse embryonic stem cells and their derivatives. Doctoral thesis, University of Liverpool.

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Abstract

The kidneys are important organs that regulate the level of water and salts in the blood, produce hormones that help to control blood pressure, and maintain homeostasis of the organism by filtering waste products. Kidney disease can either be acute or chronic, the latter progressively worsening over time to become end stage renal disease (ESRD) – a stage when kidneys are non-functional. At present, the only treatment options for ESRD are transplantation or dialysis, which both have severe drawbacks in terms of morbidity, mortality and economic cost. Moreover, the incidence of ESRD is rising annually and an alternative therapy is needed. Therefore, in order to regenerate kidney tissue or prevent worsening of the kidney condition, a new therapy should be developed. One approach is to use embryonic stem cells.

Item Type:Thesis (Doctoral)
Subjects:Q Science > QH Natural history > QH301 Biology
R Medicine > RC Internal medicine
Departments, Research Centres and Related Units:Academic Faculties, Institutes and Research Centres > Faculty of Science > Department of Biological Sciences
Refereed:No
Status:Unpublished
ID Code:1473
Deposited On:03 Jan 2012 10:44
Last Modified:04 Jan 2012 01:00

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