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The role of pyrosequencing in head and neck cancer epigenetics: correlation of quantitative methylation data with gene expression

Shaw, Richard J.; Hall, Gillian L.; Lowe, Derek; Liloglou, Triantafillos; Field, John K.; Sloan, Philip and Risk, Janet M. (2008) The role of pyrosequencing in head and neck cancer epigenetics: correlation of quantitative methylation data with gene expression. Archives of Otolaryngology, 134 (3). pp. 251-256. ISSN 0886-4470

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Official URL: http://archotol.ama-assn.org/cgi/content/full/134/...

Cited 14 times in WoS

Abstract

The role of gene promoter methylation in head and neck has been well described but with numerous methods available to detect and quantify methylation, it is unclear which methods give valuable functional data. The aim of this study is to evaluate promoter methylation quantitation using recently described pyrosequencing techniques by correlation with mRNA expression.

Item Type:Article
Uncontrolled Keywords:SQUAMOUS-CELL CARCINOMA; PROMOTER METHYLATION; ORAL-CANCER; CPG ISLANDS; E-CADHERIN; CYCLIN A1; PCR ASSAY; DNA; HYPERMETHYLATION; SITES
Subjects:R Medicine > RK Dentistry
Departments, Research Centres and Related Units:Academic Faculties, Institutes and Research Centres > Faculty of Medicine > School of Dental Sciences
Refereed:Yes
Status:Published
ID Code:262
Deposited On:11 Nov 2008 11:50
Last Modified:21 Mar 2012 11:27

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