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Scholarly Communication

Strong genetic control of emergence of human primary incisors

Hughes, T.E.; Bockmann, M.R.; Seow, K.; Gotjamanos, T.; Gully, N.; Richards, L.C. and Townsend, G.C. (2007) Strong genetic control of emergence of human primary incisors. Journal of Dental Research, 86 (12). pp. 1160-1165. ISSN 0022-0345


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Cited 12 times in WoS


Understanding of tooth eruption in humans remains incomplete. We hypothesized that genetic factors contribute significantly to phenotypic variation in emergence of primary incisors. Modelfitting was applied to data from Australian twins to quantify contributions of genetic and environmental factors to variation in timing of emergence of human primary incisors. There were no significant differences in incisor emergence times between zygosity groups or sexes. Emergence times of maxillary central incisors and mandibular lateral incisors were less variable than those of maxillary lateral incisors and mandibular central incisors. Maxillary lateral incisors displayed significant directional asymmetry, the left side emerging earlier than the right. Variation in timing of emergence of the primary incisors was under strong genetic control, with a small but significant contribution from the external environment. Estimates of narrow-sense heritability ranged from 82 to 94% in males and 71 to 96% in females.

Item Type:Article
Additional Information:Professor Grant Townsend now at The University of Liverpool.
Uncontrolled Keywords:genetic, twins, teeth, eruption, asymmetry
Subjects:R Medicine > RK Dentistry
Departments, Research Centres and Related Units:Academic Faculties, Institutes and Research Centres > Faculty of Medicine > School of Dental Sciences
Publisher's Statement:This is a copy of the accepted manuscript. The Final published article can be found at the JDR Web site. Please view the link at the Official URL Field.
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ID Code:294
Deposited On:14 Jul 2009 09:58
Last Modified:19 Mar 2012 12:05

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