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A transgenic approach to QTL analysis in a trypanotolerant mouse model

Anderson, S.J.; Noyes, H.A.; Agaba, M.; Kemp, S.J. and Archibald, A.L. (2007) A transgenic approach to QTL analysis in a trypanotolerant mouse model. In: International Symposium on Animal Genomics for Animal Health, 23-25 October 2007, OIE HQ, World Organisation for Animal Health, 12 Rue de Prony, Paris France. (Unpublished)

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Abstract

We are using a mouse model to investigate the genetic basis of trypanotolerance in African cattle. We have used a transgenic approach in order to evaluate candidate genes underlying a Quantitative Trait Locus (QTL) for trypanotolerance (Tir1) in mice identified in an earlier study. BAC clones from the trypanotolerant C57BL/6 underlying the Tir1 QTL for response to infection with Trypanosoma congolense were microinjected into F1 A/J x Balb/c (susceptible) donor oocytes fertilised with an A/J male. Transgenic animals were repeatedly backcrossed to A/J with genotyping for the transgene at every generation, and finally intercrossed prior to trypanosome challenge.

Item Type:Conference or Workshop Item (Other)
Uncontrolled Keywords:analysis; TRYPANOTOLERANT; Mouse; Model; Animal
Subjects:Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Departments, Research Centres and Related Units:Academic Faculties, Institutes and Research Centres > Faculty of Science > Department of Biological Sciences
Related URLs:
Refereed:No
Status:Unpublished
ID Code:317
Deposited On:20 Apr 2010 14:57
Last Modified:05 Mar 2012 11:22

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