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Scholarly Communication

Simulating recombination over multiple generations

Noyes, Harry and Kemp, Stephen (0009) Simulating recombination over multiple generations. In: Mouse Molecular Genetics Conference, 5-9 September 2007, Wellcome Trust Conference Centre, Hinxton Hall, Hinxton, UK. (Unpublished)

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The process of accumulation of recombinations was first modelled by Haldane in 1919 and since then a substantial body of data well supported by theory has been established which describes the recombination process on the genetic map in units of centiMorgans. The advent of genome sequences and estimates for recombination rates for each chromosome (Broman et al. 2002 Genetics 160(3): 1123-1131) makes it possible to simulate the process of recombination on the physical map in terms of megabases. These data have immediate utility for the prediction of haplotype sizes and the selection of appropriate marker density in any given generation. The simulation also lead to an equation that predicts the the observed number of recombinations in any 1Mb interval after any number of generations and between any number of founder haplotypes in a randomly mating population. When large numbers of human genome sequences become available this relationship may be useful for inferring population histories. The simulation was adapted to the model the collaborative cross in order to predict the number of generations required for complete inbreeding and the expected haplotype structure of these animals. A web interface has been created so that users can test the effect of altering the parameters of the model

Item Type:Conference or Workshop Item (Poster)
Uncontrolled Keywords:Strains; Strain; Mice; Mouse; genetics; Wellcome
Subjects:Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Departments, Research Centres and Related Units:Academic Faculties, Institutes and Research Centres > Faculty of Science > Department of Biological Sciences
ID Code:321
Deposited On:20 Apr 2010 14:30
Last Modified:20 May 2011 17:17

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