Singh, Shashi (2011) A cross-sectional paediatric pilot study of migraine, eating behaviours and adiposity. Masters thesis, University of Liverpool.
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Objective The primary aim was to compare eating behaviours between migraine cases and non-migraine headache controls. The secondary aim was to assess the relationship migraine severity and monthly headache frequency share with eating behaviours, food intake, food cravings and adiposity among migraine cases. Background Recent research has highlighted an association between migraine and adiposity, in adults and children. However the direction of causality between migraine and adiposity has not yet been established. There are overlapping neurobiological mechanisms in migraine, eating behaviours and adiposity. Migraine has been noted to affect appetite, but this has not been formally studied. This pilot study explored the biologically plausible hypothesis that migraine may lead to obesity, via alterations in appetite, food intake and food cravings. Methods A single-centre, cross-sectional, questionnaire-based, clinical migraine population pilot study was designed. The two migraine measures were migraine severity as measured by the PedMIDAS tool and monthly headache frequency. Eating behaviours were assessed using the Dutch Eating Behaviour Questionnaire (DEBQ) and Child Eating Behaviour Questionnaire (CEBQ). Food cravings were measured by the Food Craving Inventory (FCI-II) and food intake was assessed using the Food Intake Questionnaire (FIQ). Adiposity was indirectly measured using BMI z-scores. Local Research Ethics and Trust R&D approvals were granted in June 2009. Results Sixty children aged 5-17 years were recruited from neurology/general paediatric clinics. Insufficient control patients were recruited (n=7). The desire to drink subscale of the CEBQ had a significant positive correlation with the PedMIDAS scores (rs= 0.41, p= 0.01). Monthly headache frequency had a significant positive correlation with the negative marker food scores of the FIQ (rs= 0.27, p= 0.04). Conclusion The primary objective to compare eating behaviours between migraine cases and non-migraine headache controls was not achieved. Migraine severity (as measured by the PedMIDAS scores) is weakly associated with the desire to drink (as measured by the CEBQ). Monthly headache frequency is weakly associated with the intake of unhealthy foods eaten the day before. It must be noted there is only weak evidence for the conclusions given the small sample size of this pilot study.
|Item Type:||Thesis (Masters)|
|Subjects:||R Medicine > RJ Pediatrics|
|Deposited On:||23 May 2012 10:41|
|Last Modified:||03 Aug 2012 10:15|
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