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Genetic control of cutaneous leishmaniasis

Noyes, HA; Arana, FE; Rizzo, N; Kemp, SJ; Hutchinson, IV; Pravica, V; Daly, D and Arana, BA (2006) Genetic control of cutaneous leishmaniasis. In: International Congress of Parasitology XI, 6-11 August 2006, The Scottish Exhibition and Conference Centre (SECC), Glasgow Scotland.. (Unpublished)

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Abstract

Differences in expression of cytokines involved with the Th1 and Th2 responses are associated with single nucleotide polymorphisms (SNP) in the genes that encode them.. We have genotyped SNP in a panel of genes for cytokines that are known to be important in controlling the immune response. Samples were collected from the following groups: 1. Patients with chronic cutaneous leishmaniasis of more than four months. 2. Subjects with a positive Montenegro skin test but no history of disease. These individuals were expected to be resistant to the disease but not infection. 3. Individuals from the same endemic area with no history of disease and a negative skin test. This is expected to be a heterogeneous group who may or may not have been challenged Significant differences were found in allele frequencies in the TNF-beta and IL4 genes.

Item Type:Conference or Workshop Item (Other)
Uncontrolled Keywords:Control; Difference; Cytokine; Responses; Response; polymorphism; GENE; Immune; IMMUNE-RESPONSE; No; history; Disease; Infection; allele frequency
Subjects:Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Departments, Research Centres and Related Units:Academic Faculties, Institutes and Research Centres > Faculty of Science > Department of Biological Sciences
Related URLs:
Refereed:No
Status:Unpublished
ID Code:344
Deposited On:20 Apr 2010 15:14
Last Modified:20 May 2011 17:04

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