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The effect of Korean pine nut oil (PinnoThin™) on food intake, feeding behaviour and appetite: A double-blind placebo-controlled trial

Hughes, Georgina M.; Boyland, Emma J.; Williams, Nicola J.; Mennen, Louise; Scott, Corey; Kirkham, Tim C.; Harrold, Joanne A.; Keizer, Hiskias G. and Halford, Jason C.G. (2008) The effect of Korean pine nut oil (PinnoThin™) on food intake, feeding behaviour and appetite: A double-blind placebo-controlled trial. Lipids in Health and Disease, 7 . Article Number: 6. ISSN 1476-511X

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Abstract

Certain free fatty acids have been shown to have potent effects on food intake and self-reported changes in appetite; effects associated with increases in the release of endogenous cholecystokinin (CCK) and glucagon like peptide-1 (GLP-1). In the current study, the effects of a Korean pine nut oil product, PinnoThin™, at doses 2 g, 4 g and 6 g triglyceride (TG) and 2 g free fatty acid (FFA), on food intake and appetite were examined in a cross-over double-blind placebo-controlled randomised counter-balanced design in 42 overweight female volunteers. 2 g FFA PinnoThin™, given 30 minutes prior to an ad-libitum buffet test lunch, significantly reduced food intake (gram) by 9% (F(4,164) = 2.637, p = 0.036) compared to olive oil control. No significant effect of PinnoThin™ on macronutrient intake or ratings of appetite were observed. Given the recent data showing that the TG form of PinnoThin™ may also reduce appetite by increasing CCK release, the lack of any effect of the TG form found in this study could be attributed to the timing of the dosing regime. Collectively, these data suggest that PinnoThin™ may exert satiating effects consistent with its known action on CCK and GLP-1 release, and previously observed effects on self-reported appetite ratings.

Item Type:Article
Additional Information:Published: 28 February 2008. 10 pages (page numbers not for citation purposes).
Uncontrolled Keywords:GLUCAGON-LIKE PEPTIDE-1; ENERGY-INTAKE; POSTPRANDIAL LIPEMIA; CHAIN-LENGTH; FATTY-ACIDS; WEIGHT-GAIN; OBESE MEN; CHOLECYSTOKININ; SATIETY; HUMANS
Subjects:R Medicine > R Medicine (General)
Departments, Research Centres and Related Units:Academic Faculties, Institutes and Research Centres > Faculty of Science > Department of Psychology
DOI:10.1186/1476-511X-7-6
Publisher's Statement:© 2008 Hughes et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Refereed:Yes
Status:Published
ID Code:654
Deposited On:25 Jun 2008 13:35
Last Modified:19 Mar 2012 10:08

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