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Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes

Wiersma, Anje C; Leegwater, Peter A J; van Oost, Bernard A; Ollier, William E and Dukes-McEwan, Joanna (2007) Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes. BMC Veterinary Research, 3 . Article Number: 28. ISSN 1746-6148

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Abstract

Background: Dilated cardiomyopathy is a myocardial disease occurring in humans and domestic animals and is characterized by dilatation of the left ventricle, reduced systolic function and increased sphericity of the left ventricle. Dilated cardiomyopathy has been observed in several, mostly large and giant, dog breeds, such as the Dobermann and the Great Dane. A number of genes have been identified, which are associated with dilated cardiomyopathy in the human, mouse and hamster. These genes mainly encode structural proteins of the cardiac myocyte. Results: We present the annotation of, and marker development for, 14 of these genes of the dog genome, i.e. α-cardiac actin, caveolin 1, cysteine-rich protein 3, desmin, lamin A/C, LIM-domain binding factor 3, myosin heavy polypeptide 7, phospholamban, sarcoglycan δ, titin cap, α- tropomyosin, troponin I, troponin T and vinculin. A total of 33 Single Nucleotide Polymorphisms were identified for these canine genes and 11 polymorphic microsatellite repeats were developed. Conclusion: The presented polymorphisms provide a tool to investigate the role of the corresponding genes in canine Dilated Cardiomyopathy by linkage analysis or association studies.

Item Type:Article
Additional Information:8 pages (page numbers not for citation purposes). Published: 19 October 2007.
Uncontrolled Keywords:myocardial disease; dobermann; great dane; left ventricle; systolic function; cardiac myocyte; nucleotide polymorphisms; polymorphic microsatellite
Subjects:S Agriculture > SF Animal culture
Departments, Research Centres and Related Units:Academic Faculties, Institutes and Research Centres > Faculty of Veterinary Science > Department of Veterinary Clinical Science
DOI:10.1186/1746-6148-3-28
Publisher's Statement:© 2007 Wiersma et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Refereed:Yes
Status:Published
ID Code:677
Deposited On:25 Jun 2008 13:47
Last Modified:22 May 2012 10:53

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