Simpson, Deborah M.; Mobasheri, Ali; Haywood, Susan and Beynon, Robert J. (2006) A proteomics study of the response of North Ronaldsay sheep to copper challenge. BMC Veterinary Research, 2 . Article Number: 36. ISSN 1746-6148
Available under License Creative Commons Attribution.
Background: The objective of this proteomics study was to identify proteins that changed expression as a result of copper challenge in the uniquely copper sensitive North Ronaldsay sheep and further, to compare those changes in expression with the more copper tolerant Cambridge breed. Such data gives us a proteome-centered perspective of the pathogenesis of copper-induced oxidative stress in this breed. Results: Many proteins respond to copper challenge, but this study focuses on those exhibiting a differential response between the two breeds, related to liver copper content. As copper accumulated in the tissue, the pattern of expression of several proteins was markedly different, in North Ronaldsay sheep as compared to the Cambridge breed. Conclusion: The pattern of changes was consistent with the greatly enhanced susceptibility of North Ronaldsay sheep to copper-induced oxidative stress, focused on mitochondrial disturbance with consequent activation of hepatic stellate cells. The expression profiles were sufficiently complex that the response could not simply be explained as a hypersensitivity to copper in North Ronaldsay sheep.
|Additional Information:||Published: 27 December 2006. 14 pages (page numbers not for citation purposes).|
|Uncontrolled Keywords:||Cambridge sheep; pathogenesis; copper-induced oxidative stress; hepatic stellate cells|
|Subjects:||S Agriculture > SF Animal culture|
|Departments, Research Centres and Related Units:||Academic Faculties, Institutes and Research Centres > Faculty of Veterinary Science > Department of Veterinary Pathology|
Academic Faculties, Institutes and Research Centres > Faculty of Veterinary Science > Department of Veterinary Preclinical Science
|Publisher's Statement:||© 2006 Simpson et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.|
|Deposited On:||27 Jun 2008 16:00|
|Last Modified:||22 Mar 2012 12:08|
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