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Breast asymmetry and predisposition to breast cancer

Scutt, Diane; Lancaster, Gillian A. and Manning, John T. (2006) Breast asymmetry and predisposition to breast cancer. Breast Cancer Research, 8 . Article Number: R14. ISSN 1465-5411

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Abstract

asymmetry is related to several of the known risk factors for breast cancer, and that patients with diagnosed breast cancer have more breast volume asymmetry, as measured from mammograms, than age-matched healthy women. Methods In the present study, we compared the breast asymmetry of women who were free of breast disease at time of mammography, but who had subsequently developed breast cancer, with that of age-matched healthy controls who had remained disease-free to time of the present study. The study group consisted of 252 asymptomatic women who had normal mammography, but went on to develop breast cancer. The control group were 252 age-matched healthy controls whose mammograms were also normal and who remained free of cancer during the study period. Breast volume was calculated from the cranio-caudal mammograms for each group, and the relationships between asymmetry, established risk factors and the presence or absence of breast cancer were explored. Results The group who went on to develop breast cancer had higher breast asymmetry than controls (absolute asymmetry odds ratio 1.50 per 100 ml, confidence interval (CI) 1.10, 2.04; relative asymmetry 1.09, CI 1.01, 1.18), increased incidence of family history of breast cancer, lower age at menarche, later menopause, later first pregnancies and a higher frequency of high risk breast parenchyma types. Conditional logistic regression analysis showed that breast asymmetry, height, family history of breast cancer, age at menarche, parenchyma type and menopausal status were significant independent predictors of breast cancer. When age at menopause was included in the model for the subgroup of post-menopausal women, absolute breast fluctuating asymmetry (FA) and relative breast FA remained significant effects. Conclusion Breast asymmetry was greater in healthy women who later developed breast cancer than in women who did not.

Item Type:Article
Additional Information:Published: 20 Mar 2006. 7 pages (page numbers not for citation purposes).
Uncontrolled Keywords:SWALLOW HIRUNDO-RUSTICA; MALE SEXUAL ORNAMENTS; FLUCTUATING ASYMMETRY; DEVELOPMENTAL STABILITY; TRANSGENIC MICE; MAMMOGRAPHIC DENSITY; FEMALE PREFERENCE; MAMMARY-GLANDS; SELECTION; PATTERNS
Subjects:R Medicine > R Medicine (General)
Departments, Research Centres and Related Units:Academic Faculties, Institutes and Research Centres > Faculty of Medicine > School of Health Sciences
Academic Faculties, Institutes and Research Centres > Research Centres > Medical Statistics and Health Evaluation, Centre for
DOI:10.1186/bcr1388
Publisher's Statement:© 2006 Scutt et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Related URLs:
Refereed:Yes
Status:Published
ID Code:770
Deposited On:02 Jul 2008 10:44
Last Modified:27 Feb 2012 13:40

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