Smyth, Rosalind L. (2002) Asthma: a major pediatric health issue. Respiratory Research, 3 (suppl 1). S3-S7. ISSN 1465-993X (Online); 1465-9921 (Print)
Available under License Creative Commons Attribution.
Cited 20 times in WoS
The incidence, prevalence, and mortality of asthma have increased in children over the past three to four decades, although there has been some decline in the most recent decade. These trends are particularly marked and of greatest concern in preschool children. Internationally, there are huge variations among countries and continents, as demonstrated by the International Study of Asthma and Allergies in Childhood. In general, asthma rates were highest in English-speaking countries (UK, New Zealand, Australia, and North America) and some Latin American countries (Peru and Costa Rica), and lowest in South Korea, Russia, Uzbekistan, Indonesia, and Albania. There is currently no unifying hypothesis to explain these trends or any associated risk factors. Environmental factors that may lead to asthma include air pollution; genetic factors, the hygiene hypothesis, and lifestyle differences also play potentially causative roles. Asthma may develop as a result of persistent activation of the immune system alone or in combination with physiologic airway remodeling in early childhood. Further studies are needed to confirm this hypothesis.
|Additional Information:||Published: 24 June 2002.|
|Uncontrolled Keywords:||asthma; environmental factors; epidemiology; immunopathogenesis; international data; time trends|
|Subjects:||R Medicine > RJ Pediatrics|
|Departments, Research Centres and Related Units:||Academic Faculties, Institutes and Research Centres > Faculty of Medicine > School of Reproductive & Developmental Medicine|
|Publisher's Statement:||© 2002 Smyth; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.|
|Deposited On:||07 Jul 2008 16:12|
|Last Modified:||25 Apr 2012 09:14|
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