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Pitfalls and procedures in the histopathological diagnosis of oral and oropharyngeal squamous cell carcinoma and a review of the role of pathology in prognosis

Woolgar, Julia A. and Triantafyllou, Asterios (2009) Pitfalls and procedures in the histopathological diagnosis of oral and oropharyngeal squamous cell carcinoma and a review of the role of pathology in prognosis. Oral Oncology, 45 (4-5). pp. 361-385. ISSN 1368-8375

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Cited 19 times in WoS

Abstract

Summary Histopathological assessment of formalin-fixed biopsy tissue and surgical resection specimens remains the cornerstone of cancer diagnosis and pathological staging in routine clinical practice. In recent years, standard protocols for reporting head and neck cancer have been widely used and these have improved the general level of the pathological assessment. In this article, we look beyond the standard protocols and deal with potential difficulties and pitfalls in the assessment of incisional biopsy specimens, surgical resection specimens and neck dissections. We draw attention to possible shortcomings and issues requiring clarification. Emphasis is given to precise histopathological definitions, histopathological detection and differential diagnosis. The approach is a practical one - a consideration of common experiences and dilemmas faced by the reporting pathologist, and where possible, we offer guidance and practical tips. The article concludes with a brief consideration of the prognostic value of accurate histopathological staging.

Item Type:Article
Additional Information:Issue: April-May 2009. Available online 11 October 2008.
Uncontrolled Keywords:Oral cancer; Oropharyngeal cancer; Squamous cell carcinoma; Histopathology
Subjects:R Medicine > RK Dentistry
Departments, Research Centres and Related Units:Academic Faculties, Institutes and Research Centres > Faculty of Medicine > School of Dental Sciences
DOI:10.1016/j.oraloncology.2008.07.016
Refereed:Yes
Status:Published
ID Code:938
Deposited On:26 Nov 2008 12:18
Last Modified:19 May 2011 19:35

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